In a press release from the University of California (UC), Davis Health, Nancy E. Lane, MD, the Distinguished Professor of Medicine and Rheumatology in the Department of Internal Medicine at the UC Davis School of Medicine, detailed new research in the fields of osteoarthritis and osteoporosis. Dr. Lane recently found that the novel compound LLPA2A-alendronate may be effective at restoring tissue loss for patients with these diseases. Currently, she and her colleagues are exploring how blood vessels in the bones may be impacted by age, inflammation, and anti-inflammatory medications; how intramuscular fat may promote weakness; and the efficacy of exercise in older patients with knee osteoarthritis. The research team is also using biopsies, biomarkers, imaging techniques, and physical and cognitive examinations to study the biological processes that lead to muscle deterioration and loss of mobility for older patients. Dr. Lane recommended that menopausal female patients and male patients aged 70 years and older should visit their physicians to screen for osteoarthritis risk factors. She urged those who want to maintain healthy bones and joints to lose weight if they are overweight, in addition to exercising regularly. Dr. Lane hopes to soon develop medications that patients can take to target and prevent muscle weakness.
May 25, 2023