A review article authored by Ellen M. Gravallese, MD, of the Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, and Gary S. Firestein, MD, of the Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, in The New England Journal of Medicine provides a comprehensive overview of seropositive rheumatoid arthritis. The authors go over epidemiology and disease classification; genetic risk and epigenetic factors; mucosal inflammation, altered peptides, and clinical disease; synovitis; pathogenesis; long-term disease and its consequences; and therapeutics.
May 25, 2023