The prevalence of celiac disease in patients with systemic lupus erythematosus may be comparable to that in the general population, according to a recent systematic review and meta-analysis published by Sotoodeh et al in Lupus Science and Medicine. Previous studies have not come to a clear consensus regarding the prevalence of celiac disease among patients with lupus. Investigators used the Medline, Embase, Cochrane, and Web of Science Core Collection databases to identify 2,053 studies exploring the association between lupus and celiac disease that were published between January 1, 1990, and July 9, 2023. They narrowed down the studies to 11 that met the inclusion criteria, which included 1,238 patients with lupus—14 of whom had biopsy-confirmed celiac disease. The investigators found that the weighted pooled prevalence of celiac disease in the sample was 0.7% (95% CI = 0.0%–1.8%). Further, among 1,063 patients with lupus, the weighted pooled prevalence of celiac disease serological markers was 3.7% (95% CI = 1.4%–6.7%). They reported no correlations between the prevalence of celiac disease and study characteristics, demographics, and quality assessment scores. The investigators concluded that patients with lupus may not need to undergo screening for celiac disease unless physicians suspect that they may have risk factors or clinical indicators of the disease.