Exercise therapy may be a safe and effective nonpharmacologic option to limit flares, boost energy, and reduce pain among patients with systemic lupus erythematosus, according to a new study published by Spinelli et al in Autoimmunity Reviews. Patients’ interferon gene signature may be responsible for triggering disease development and progression. Previous studies have noted that interferon gamma and interferon alpha oversignaling can combine in cytokine/chemokine overexpression to worsen autoimmunity. In the new study, the investigators discovered that exercising may reduce levels of inflammatory cytokines associated with interferon signatures and rebalance the immune system without producing adverse effects. Further, exercise may improve patients’ cardiorespiratory and musculoskeletal health, aerobic fitness, physical energy, and overall quality of life. Despite the positive findings, the investigators noted that exercise therapy is currently not included in standard-care regimens for patients with lupus, who have often reported avoiding exercise as a result of kinesiophobia. However, the investigators emphasized that leading a sedentary lifestyle can exacerbate lupus symptoms as well as decrease physical health and quality of life. Further studies may be needed to better understand the full benefits of exercise therapy in patients with lupus.