Investigators have found that male patients with inflammatory joint diseases are less likely to be childless compared with the general population, and in fact have a higher number of children on average, according to a recent Norwegian study published by Sigmo et al in the Annals of the Rheumatic Diseases. In a nationwide, population-based, retrospective cohort study, investigators used the Norwegian Arthritis Registry and the National Population Register to identify about 11,000 male patients with inflammatory joint diseases—including rheumatoid arthritis (37%), psoriatic arthritis (33%), and spondyloarthritis (30%)—and about 54,000 age- and county-of-residence–matched controls. They then used the Medical Birth Registry of Norway to assess data on the mean number of children per participant as a proxy for fertility. Between 1967 and August 2021, a total of 65,190 patients with inflammatory joint diseases and controls had 111,246 children. The mean number of children per patient with inflammatory joint diseases was 1.80 vs 1.69 among controls. The investigators also discovered that 21% of patients with inflammatory joint diseases were childless compared with 27% of controls. Further, among those aged 30 to 39 years diagnosed with inflammatory joint diseases after the year 2000, 22% were childless, vs 32% of controls. The investigators noted that the findings were consistent regardless of age at diagnosis (excluding patients diagnosed between 0 and 19 years of age). The investigators concluded that more research may be needed to determine whether unknown factors related to inflammatory joint disease development, immune-modulating drugs, or psychological and socioeconomic characteristics may influence fertility in this patient population.


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