Patients with systemic lupus erythematosus are at a higher risk of a number of pregnancy- and delivery-related adverse outcomes, such as intrauterine growth restriction; premature delivery; the need for a blood transfusion during delivery; and maternal cerebrovascular disorder, eclampsia, acute renal failure, and more. In a study published by Mehta et al in RMD Open, researchers performed a retrospective analysis on data pulled from the National Inpatient Sample from 2008 to 2017. The authors also determined that the patients with systemic lupus erythematosus included in this data set were more likely to be older, Black, and insured via Medicare, as well as to have received treatment at an urban teaching hospital and a medium- or large-sized hospital compared to patients without systemic lupus erythematosus. The study authors concluded, “Our study gives population estimates of an increase in fetal and severe maternal morbidity in patients with systemic lupus erythematosus compared with those without systemic lupus erythematosus. Despite extensive efforts over the years, there remains substantial risk for both maternal and fetal complications. This information serves to inform both patients and their doctors, promote individual level counselling, and thereby improve outcomes.”


Sources & References