In a report published by Wong et al in Science Advances, researchers explained that by studying chronically sun-exposed skin, they found that the mutational load and allele frequency of individual mutations increased linearly with ultraviolet (UV) radiation exposure. The team collected a 2-mm punch biopsy from the forearm skin—an area that receives regular sun exposure—of 37 study participants. They found that the mutational load in the skin was also associated with keratinocyte cancer load and number of keratinocyte lesions. Lastly, targeting the mutational load through therapies such as ablation may help to either treat existing cancers or prevent cancers from developing.