Researchers have uncovered skin biomarkers that may predict the early onset of food allergies in infants, according to a recent study published by Berdyshev et al in The Journal of Allergy and Clinical Immunology. Food allergies often present themselves in early childhood and may or may not exist comorbidly alongside atopic dermatitis. Researchers performed lipidomic analyses via liquid chromatography–tandem mass spectrometry as well as cytokine determination via Meso Scale Discovery U-Plex assay on skin tape strips collected from the forearms of 129 2-month-old patients prior to the clinical manifestation of food allergies or atopic dermatitis. The patients were then monitored for up to 2 years to confirm the presence or absence of the conditions. The researchers discovered that 7% (n = 9) of the patients developed food allergies and 7% (n = 9) of them developed food allergies concomitantly with atopic dermatitis. Compared with the patients who did not develop either condition, the patients who later developed food allergies alone or alongside atopic dermatitis had higher absolute amounts of unsaturated (N24:1) (C18-sphingosine) ceramide and (N26:1) (C18-sphingosine) ceramide and relative percentages within the molecular group. Further, the patients who developed food allergies had upregulated interleukin-33 levels but not upregulated thymic stromal lymphopoietin, whereas those who developed atopic dermatitis had upregulated thymic stromal lymphopoietin but not interleukin-33 levels. The researchers highlighted that the combination of dysregulated lipids and cytokines measured with skin tape strips may be predictive of future food allergies, with an odds ratio of 101.4 (95% confidence interval = 5.4–1,910.6). In a companion press release on the findings from National Jewish Health, the study authors concluded: “Ultimately, we want to identify [patients] at risk for food allergies and address skin barrier abnormalities early to prevent the development of these conditions.”