The theoretical risk of opioid addiction may influence the choice of pain medication in patients who undergo Mohs micrographic surgery, according to a new study published by Nugent et al in JAMA Dermatology. In the new prospective choice experiment, investigators asked 295 patients who underwent Mohs micrographic surgery from August 2021 to April 2022 to respond to a survey regarding their preference for opioids in combination with over-the-counter pain medications or over-the-counter medications alone when faced with varying degrees of opioid addiction and pain. The investigators discovered that as the risk of opioid addiction increased, the respondents were more likely to select over-the-counter medications to relieve their postsurgical pain—irrespective of their level of pain. They found that 34% (n = 101) of the respondents answered that they would never consider opioids to manage their pain, and 50% (n = 147) stated that they were concerned about becoming addicted to opioids. When faced with a low risk of addiction, an equal number of respondents expressed that they were willing to take opioids or over-the-counter medications alone. However, when the risk of opioid addiction was higher, a majority of the respondents preferred treatment with only over-the-counter medications. The investigators highlighted the importance of shared decision-making when discussing postsurgical pain management strategies with patients.