In a new review published by Almet et al in the Journal of Investigative Dermatology, investigators outlined a potential roadmap to develop a consensus Human Skin Cell Atlas. The investigators explained that the atlas can serve as a comprehensive reference to single-cell composition of normal human skin, including cell types, cell states, and their molecular signatures. Widespread participation by researchers specializing in dermatology—with expertise in conserved gene expression features of distinct skin types—during the atlas’ development phase may be critical to achieving broader acceptance. With the new roadmap, the investigators hope to uncover conserved and varying human skin cell populations and molecular differences associated with skin diseases, minimize biases in cell type enrichments and exclusions as well as batch effects, and identify the barriers during skin sampling that may hinder diverse and global data representation. The investigators plan to make the Human Skin Cell Atlas available for personalized diagnostics and semiautomated mapping of patient-specific changes in future single-cell RNA sequencing data as an open-source online resource upon its completion.