The risk of developing skin cancer may be twofold for patients with lymphedema, according to a recent study published by Anand et al in Mayo Clinic Proceedings. Investigators examined the data of 4,437 patients diagnosed with lower-extremity lymphedema between 2000 and 2020. Compared with controls, patients with lymphedema had an increased risk of all common types of skin cancer—including melanoma and angiosarcoma—and a significantly higher frequency of developing basal cell carcinoma and squamous cell carcinoma on the lower extremities. Among patients who had lymphedema in one leg, that extremity had nearly three times the likelihood of developing skin cancer compared with the unaffected leg. In a companion press release on the findings from the Mayo Clinic, the study authors concluded: “Our findings suggest the need for a relatively high degree of suspicion of skin cancer at sites with lymphedema. There is a need for raising awareness in clinicians seeing patients with lymphedema, and these patients may need regular skin cancer screenings, since early detection of skin cancer is critical.”