Investigators have identified new genetic variants that may be linked to male-pattern hair loss, according to a recent study published by Henne et al in Nature Communications. Researchers used the UK Biobank to conduct gene-based and single-variant analyses of exome-sequencing data from 72,469 male patients. After performing rare variant collapsing tests, five genes—EDA2R, WNT10A, HEPH, CEPT1, and EIF3F—were found to potentially be associated with an increased risk of male-pattern hair loss. Additionally, these genes were enriched for genes that may be responsible for monogenic trichoses. The investigators hope their new findings can help broaden the allelic spectrum and provide insights into the pathobiology of male-pattern hair loss.