Preclinical research published by Wheeler et al in JID Innovations showed that linoleic acid—a fatty acid found in vegetable oils, nuts, and seeds that is predominant in Western diets—may increase pain and temperature, but not itch, in psoriatic lesions. The study, which used calcium imaging, mouse genetics, behavior, and pharmacology, showed that when two types of linoleic acid-derived lipids, or oxylipids—9,10-epoxy-13-hydroxy-octadecenoate (9,13-EHL) and 9,10,13-trihydroxy-octadecenoate (9,10,13-THL)—bind to neuronal receptors, they in turn activate neurons that express TRPA1 and TRPV1 receptors, which are involved in pain and temperature sensitivity.
May 24, 2023