Sexually diverse individuals may have an increased risk of developing atopic diseases, according to a new report published by Rypka et al in JAMA Dermatology. In a cross-sectional study, investigators used the 2021 National Health Interview Survey to analyze the data of 27,012 individuals—25,701 of whom identified as heterosexual and 1,311 of whom identified as sexually diverse (gay, lesbian, bisexual, or other). The investigators then examined the associations between sexual orientation and the risk of atopic diseases such as atopic dermatitis, asthma, and allergic rhinitis. Compared with heterosexual individuals, sexually diverse individuals reported a higher prevalence of atopic dermatitis at 11.1% vs 7.2% (adjusted odds ratio [OR] = 1.49, 95% confidence interval [CI] = 1.19–1.86), asthma at 12.0% vs 7.8% (adjusted OR = 1.39, 95% CI = 1.13–1.71), and allergic rhinitis at 33.7% vs 25.6% (adjusted OR = 1.30, 95% CI = 1.11–1.51). The investigators suggested that environmental, socioeconomic, and sociocultural factors may all play a role in the higher risk seen among sexually diverse individuals. For instance, sexually diverse individuals may be more likely to reside in urban areas with lower rates of stigmatization and discrimination but higher concentrations of disease triggers such as air pollutants and secondhand smoke. Previous studies have demonstrated that similar influences may have an effect on disease risk among patients belonging to racial and ethnic minorities. The investigators concluded that further research may be needed to more fully understand the factors that may be contributing to disparities in the incidence of atopic diseases in this patient population.