Investigators may have uncovered factors influencing long-term oral antibiotic prescriptions in patients with acne, according to a recent study published by Festok et al in JAMA Dermatology. Although current guidelines advise limiting the use of long-term oral antibiotics to less than 3 months for patients with acne, dermatologists are known to prescribe more of these antibiotics compared with clinicians in other specialties. In the recent study, investigators asked 30 stakeholders—including dermatologists, infectious disease physicians, dermatology resident physicians, and nonphysician clinicians—to complete an online survey and semistructured video interviews between March and August 2021. They sought to identify facilitators and/or barriers to long-term oral antibiotic prescriptions for acne. Among the respondents, knowledge of antibiotic guideline recommendations was high, and many of them considered antibiotic stewardship to be a professional responsibility. They identified five salient factors contributing to long-term oral antibiotic prescriptions: a perceived lack of evidence to justify dermatologic practice changes, challenges navigating patient demands and satisfaction, discomfort communicating about contraception, barriers related to the iPLEDGE program, and an absence of an effective system to track antibiotic stewardship progress. The investigators emphasized the critical need to consider the newly identified factors in the design and implementation of a novel antibiotic stewardship program in the clinical care of patients with acne.